SLU-PP-332

What It Is

SLU-PP-332 is a small-molecule agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ), which play key roles in cellular energy metabolism and mitochondrial biogenesis. Research has shown that activating these receptors enhances oxidative metabolism, improves mitochondrial function, and mimics the physiological effects of endurance exercise. Preclinical studies have explored SLU-PP-332 for its potential to improve metabolic efficiency, reduce fat accumulation, and promote energy expenditure in models of diet-induced obesity and metabolic dysfunction.

Benefits (Research Has Shown)

Exercise-Mimetic Effects: Research indicates SLU-PP-332 activates pathways associated with aerobic training, increasing mitochondrial density and endurance-related gene expression.
Fat Oxidation: Studies show enhanced fatty acid metabolism and reduced adiposity without increased physical activity.
Energy Regulation: Research demonstrates higher resting energy expenditure and improved metabolic flexibility in animal models.
Muscle Support: Data suggest a shift toward oxidative (fat-burning) muscle fibers, supporting endurance and recovery.
Metabolic Health: Preliminary findings show improved insulin sensitivity and lipid profiles in preclinical studies.

Who Might Use It

• Metabolic research teams: Studying exercise-mimetic compounds or ERR pathway activation.
• Mitochondrial function researchers: Exploring agents that enhance energy production.
• Obesity and metabolism labs: Investigating pharmacological tools for fat-mass reduction and metabolic health.
• Sports science and endurance physiology studies: Examining molecular adaptations linked to improved performance and recovery.

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